Module	Function
Haplogroup classification module	classify haplogroup according to mtDNA control region sequence
	classify haplogroup according to variants in mtDNA control region
	classify haplogroup according to the mtDNA genome sequence lacking D-loop region
	classify haplogroup according to variants in the mtDNA genome lacking D-loop region
	classify haplogroup according to the whole mtDNA genome sequence
	classify haplogroup according to variants in the whole mtDNA genome
	transform variants between rCRS as reference seq. and RSRS as reference seq.
Detailed parsing module	display the location of the variant
	display interspecies conservation index of the variant
	display change of amino acid status
	identify potentially pathogenic mutations based on the literatures
	scan possible errors with the help of speculated haplogroups
Database module	retrieve and download mtDNA genomes of multiple species
	retrieve and download human complete mtDNA sequences
	retrieve pathogenic mutations in human mtDNA
	retrieve human mitochondria-located proteins
	retrieve haplogroup-specific variation motifs
Statistical analysis module	perform Fisher’s exact test
	perform Pearson’s Chi-square test
	perform Yates’ Chi-square test