E-mail:  lingxu0502@yahoo.com

Education and Professinal Appointment:
2018.1 - Present: Associate Professor, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
2014.11 - 2018.1: Research Assistant, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
2011.9 - 2014.11: Ph.D. candidate, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
2009.9 - 2011.9: M.S., Kunming Institute of Zoology, the Chinese Academy of Sciences
2004.9 - 2009.6: B.A., College of Animal Medicine, Huazhong Agricultural University

Publication:

First author:
1. Zeng J#, Xie X#, Feng X-L#, Xu L#, Han J-B, Yu D, Zou Q-C, Liu Q, Li X, Ma G, Li M-H*, Yao Y-G*. 2022. 
     Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice. 
     EBioMedicine, 75: 1038.	

2. Xu L#, Yu D#, Yao Y-L, Gu T, Zheng X, Wu Y, Luo R-H, Zheng Y-T, Zhong J, Yao Y-G*. 2020. 
     Tupaia MAVS is a dual target during hepatitis C virus infection for innate immune evasion and viral replication via NF-κB. 
     The Journal of Immunology, 205: 2091-2099.

3. Xu L#, Yu D#, Ma Y, Yao Y-L, Luo R, Feng X, Cai H, Han J, Wang X, Li M, Ke C, Zheng Y-T*, Yao Y-G*. 2020. 
     COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2. 	
     Zoological Research, 41: 517-526.

4. Xu L, Yu D, Peng L, Wu Y, Fan Y, Gu T, Yao Y-L, Zhong J, Chen X, Yao Y-G*. 2020. 
     An alternative splicing of Tupaia STING modulated anti-RNA virus responses by targeting MDA5-LGP2 and IRF3. 
     The Journal of Immunology, 204: 3191-3204.

5. Xu L, Yu D, Fan Y, Liu Y-P, Yao Y-G*. 2019. 
    Evolutionary selection on MDA5 and LGP2 in the chicken preserves antiviral competence in the absence of RIG-I. 
   Journal of Genetics and Genomics, 46: 499-503.

6. Xu L, Peng L, Gu T-L, Yu D, Yao Y-G*. 2019. 
     The 3′UTR of human MAVS mRNA contains multiple regulatory elements for the control of protein expression and subcellular localization. 
     Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1862: 47-57.

7. Xu L#, Yu D#, Fan Y, Peng L, Wu Y, Yao Y-G*. 2016. 
     Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew. 
     Proceedings of the National Academy of Sciences of the United States of America, 113: 10950 - 10955.

Corresponding author:
1. Gu T-L, Yu D, Fan Y, Wu Y, Yao Y-L, Xu L*, Yao Y-G*. 2019. 
     Molecular identification and antiviral function of the guanylate-binding protein (GBP) genes in the Chinese tree shrew (Tupaia belangeri chinesis). 
     Developmental and Comparative Immunology, 96: 27-36.

Others:
1. Gu T, Yu D, Xu L, Yao Y-L, Yao Y-G*. 2021. 
    Tupaia GBP1 interacts with STING to initiate autophagy and restrict herpes simplex virus type 1 infection. 
    The Journal of Immunology, 207: 2673-2680. 

2. Zheng X, Xu L, Ye M, Gu T, Yao Y-L, Lv L-B, Yu D*, Yao Y-G*. 2022. 
     Characterizing the role of Tupaia DNA damage inducible transcript 3 (DDIT3) gene in viral infections. 
     Developmental and Comparative Immunology, 127: 104307.

3. Liu Q, Gu T, Su L-Y, Jiao L, Qiao X, Xu M, Xie T, Yang L-X, Yu D, Xu L, Chen C*, Yao Y-G*. 2021. 
     GSNOR facilitates antiviral innate immunity by restricting TBK1 cysteine S-nitrosation. 
     Redox Biology, 47: 102172.

4.  Ye M, Zhang J-Y, Yu D, Xu M, Xu L, Lv L-B, Zhu Q-Y, Fan Y, Yao Y-G*. 2021. 
      Comprehensive annotation of the Chinese tree shrew genome by large-scale RNA sequencing and long-read isoform sequencing. 
      Zoological Research, 42: 692-709.
 
5. Gu T, Yu D, Xu L, Yao Y-L, Zheng X, Yao Y-G*. 2021. 
     Tupaia guanylate-binding protein 1 interacts with vesicular stomatitis virus phosphoprotein and represses primary transcription of the viral genome. 
     Cytokine, 138: 155388.

6. Yao Y-L, Yu D, Xu L, Gu T, Li Y, Zheng X, Bi R, Yao Y-G*. 2020. 
     Tupaia OASL1 promotes cellular antiviral immune responses by recruiting MDA5 to MAVS. 
     The Journal of Immunology, 205: 3419-3428.

7. Gu T-L, Yu D, Li Y, Xu L, Yao Y-L, Yao Y-G*. 2019. 
     Establishment and characterization of an immortalized renal cell line of the Chinese tree shrew (Tupaia belangeri chinesis). 
     Applied Microbiology and Biotechnology, 103: 2171-2180.

8. Yao Y-L, Yu D, Xu L, Fan Y, Wu Y, Gu T-L, Chen J, Lv L-B, Yao Y-G*. 2019. 
     Molecular characterization of the 2′,5′-oligoadenylate synthetase family in the Chinese tree shrew (Tupaia belangeri chinensis). 
     Cytokine, 114: 106-114.

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