E-mail: yudandan@mail.kiz.ac.cn

Education and Professional Appointments:
2017.1 - Present: Associate Professor, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
2008.1 - 2016.12: Research Assistant, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
2005.8 - 2007.12: Research Assistant, Department of Swine Infectious Diseases, Shanghai Veterinary Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
2002.9 - 2005.6: B.A., Nanjing Agricultural University, Nanjing, Jiangsu, China.

Publications:
First author (#) and Corresponding author (*)

First author:
1. Xu L#, Yu D#, Yao Y-L, Gu T, Zheng X, Wu Y, Luo R-H, Zheng Y-T, Zhong J, Yao Y-G*. 2020. 
   Tupaia MAVS is a dual target during hepatitis C virus infection for innate immune evasion and viral replication via NF-κB. 
   The Journal of Immunology, 205: 2091-2099.

2. Xu L#, Yu D#, Ma Y, Yao Y-L, Luo R, Feng X, Cai H, Han J, Wang X, Li M, Ke C, Zheng Y-T*, Yao Y-G*. 2020. 
   COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2. 
   Zoological Research, 41: 517-526.

3. Xu L#, Yu D#, Fan Y, Peng L, Wu Y, Yao Y-G*. 2016.
   Loss of RIG-I leads to a functional replacement with MDA5 in the Chinese tree shrew. 
   Proceedings of the National Academy of Sciences of the United States of America, 113: 10950 - 10955.

4. Yu D, Wu Y, Xu L, Fan Y, Peng L, Xu M, Yao Y-G*. 2016. 
   Identification and characterization of toll-like receptors (TLRs) in the Chinese tree shrew (Tupaia belangeri chinensis). 
   Developmental and Comparative Immunology, 60: 127-138.
   
5. Yu D, Xu L, Liu X-H, Fan Y, Lv L-B, Yao Y-G*. 2014. 
   Diverse interleukin-7 mRNA transcripts in Chinese tree shrew (Tupaia belangeri chinensis).
   PLoS One, 9: e99859.

6. Yu D, Xu L, Peng L, Chen S-Y, Liu Y-P, Yao Y-G*. 2014. 
   Genetic variations of mitochondrial antiviral signaling gene (MAVS) in domestic chickens. 
   Gene, 545: 226-232.

7. Yu D, Jia X, Zhang A-M, Li S, Zou Y, Zhang Q*, Yao Y-G*. 2010.
   Mitochondrial DNA sequence variation and haplogroup distribution in Chinese patients with LHON and m.14484T>C.
   PLoS One, 5: e13426.

8. Yu D, Jia X, Zhang A-M, Guo X, Zhang Y-P, Zhang Q*, Yao Y-G*. 2010.
   Molecular characterization of six Chinese families with m.3460G>A and Leber hereditary optic neuropathy. 
   Neurogenetics, 11: 349-356.

9. Yu D, Lv J, Sun Z, Zheng H, Lu J, Yuan S*. 2009. 
   Reverse genetic manipulation of the overlapping coding regions for structural proteins of the type II porcine reproductive and respiratory syndrome virus. 
   Virology, 383(1): 22-31.

Corresponding author:
1. Zheng X, Xu L, Ye M, Gu T, Yao Y-L, Lv L-B, Yu D*, Yao Y-G*. 2022. 
   Characterizing the role of Tupaia DNA damage inducible transcript 3 (DDIT3) gene in viral infections. 
   Developmental and Comparative Immunology, 127: 104307.
   
2. Zhang X, Yu D*, Wu Y, Gu T, Ma N, Dong S*, Yao Y-G. 2020. 
   Establishment and transcriptomic features of an immortalized hepatic cell line of the Chinese tree shrew. 
   Applied Microbiology and Biotechnology, 104: 8813-8823.
   
3. Lu J, Zou Y, Xu L, Yang R-X, Fan Y, Zhang W, Yu D*, Yao Y-G. 2014. 
   IDH1 p.R132 mutations may not be actively involved in the carcinogenesis of hepatocellular carcinoma. 
   Medical Science Monitor, 20: 247-254.

Others:
1. Chen J-Q, Zhang Q, Yu D, Bi R, Ma Y, Li Y, Lv L-B*, Yao Y-G*. 2022. 
   Optimization of milk substitutes for the artificial rearing of Chinese tree shrews (Tupaia belangeri chinensis). 
   Animals, 12: 1655. 

2.	Zeng J*, Xie X, Feng X-L, Xu L, Han J-B, Yu D, Zou Q-C, Liu Q, Li X, Ma G, Li M-H*, Yao Y-G*. 2022. 
    Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice. 
    EBioMedicine, 75: 1038.
	
3. Gu T, Yu D, Xu L, Yao Y-L, Yao Y-G*. 2021. 
   Tupaia GBP1 interacts with STING to initiate autophagy and restrict herpes simplex virus type 1 infection. 
   The Journal of Immunology, 207: 2673-2680. 
   
4. Liu Q, Gu T, Su L-Y, Jiao L, Qiao X, Xu M, Xie T, Yang L-X, Yu D, Xu L, Chen C*, Yao Y-G*. 2021. 
   GSNOR facilitates antiviral innate immunity by restricting TBK1 cysteine S-nitrosation. 
   Redox Biology, 47: 102172.
   
5. Ye M, Zhang J-Y, Yu D, Xu M, Xu L, Lv L-B, Zhu Q-Y, Fan Y, Yao Y-G*. 2021. 
   Comprehensive annotation of the Chinese tree shrew genome by large-scale RNA sequencing and long-read isoform sequencing. 
   Zoological Research, 42: 692-709.
   
6. Gu T, Yu D, Xu L, Yao Y-L, Zheng X, Yao Y-G*. 2021. 
   Tupaia guanylate-binding protein 1 interacts with vesicular stomatitis virus phosphoprotein and represses primary transcription of the viral genome. 
   Cytokine, 138: 155388.

7. Yao Y-L, Yu D, Xu L, Gu T, Li Y, Zheng X, Bi R, Yao Y-G*. 2020. 
   Tupaia OASL1 promotes cellular antiviral immune responses by recruiting MDA5 to MAVS. 
   The Journal of Immunology, 205: 3419-3428.

8. Xu L, Yu D, Peng L, Wu Y, Fan Y, Gu T, Yao Y-L, Zhong J, Chen X, Yao Y-G*. 2020. 
   An alternative splicing of Tupaia STING modulated anti-RNA virus responses by targeting MDA5-LGP2 and IRF3. 
   The Journal of Immunology, 204: 3191-3204.

9. Xu L, Yu D, Fan Y, Liu Y-P, Yao Y-G*. 2019. 
   Evolutionary selection on MDA5 and LGP2 in the chicken preserves antiviral competence in the absence of RIG-I. 
   Journal of Genetics and Genomics, 46: 499-503.

10. Gu T-L, Yu D, Fan Y, Wu Y, Yao Y-L, Xu L*, Yao Y-G*. 2019. 
    Molecular identification and antiviral function of the guanylate-binding protein (GBP) genes in the Chinese tree shrew (Tupaia belangeri chinesis). 
    Developmental and Comparative Immunology, 96: 27-36.

11. Gu T-L, Yu D, Li Y, Xu L, Yao Y-L, Yao Y-G*. 2019. 
    Establishment and characterization of an immortalized renal cell line of the Chinese tree shrew (Tupaia belangeri chinesis). 
    Applied Microbiology and Biotechnology, 103: 2171-2180.

12. Yao Y-L, Yu D, Xu L, Fan Y, Wu Y, Gu T-L, Chen J, Lv L-B, Yao Y-G*. 2019. 
    Molecular characterization of the 2′,5′-oligoadenylate synthetase family in the Chinese tree shrew (Tupaia belangeri chinensis). 
    Cytokine, 114: 106-114.

13. Xu L, Peng L, Gu T-L, Yu D, Yao Y-G*. 2019. 
	The 3′UTR of human MAVS mRNA contains multiple regulatory elements for the control of protein expression and subcellular localization. 
    Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1862: 47-57.


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